James B. Rawlings Research Group


Daniel Patience
B.S. Ch.E., University of Canterbury
Ph.D., University of Wisconsin-Madison, 2002
daniel[AT]bevo[DOT]che[DOT]wisc[DOT]edu

Current Work

Current practice of crystal engineering can be characterized as largely empirical. This state of development leads to large risk associated with scale-up and operation of crystallization processes. The resulting final product's crystal size and shape distribution cannot be reliably produced. Small, uncontrolled operational changes, such as feed impurity level and vessel mixing, can lead to large changes in the final product properties. As these types of processing problems arise, researchers and operators often have no recourse but to address them in a trial and error fashion without guidance from a systematic approach based on sound scientific principles and without exploiting the latest particle measurement technologies. The challenges faced by practitioners are especially pronounced when addressing manufacture of new products. Generating product and process understanding quickly is essential if manufacturers wish to capitalize on their large investment in new product discovery research.

This research develops and assembles tools to enable improved crystal engineering: reliable modeling frameworks, sound particle size and shape measurement technology, nucleation and growth kinetic determination from data, optimal operations policies given the identified models, and prediction of final product size, shape and purity.

This project is currently focused on the following four areas.


Publications

1
Eric L. Haseltine, Daniel B. Patience, and James B. Rawlings.
On the stochastic simulation of particulate systems.
Chem. Eng. Sci., 60(10):2627-2641, 2005.

2
Daniel. B. Patience, Philip. C. Dell'Orco, and James B. Rawlings.
Optimal operation of a seeded pharmaceutical crystallization with growth-dependent dispersion.
Org. Process Res. Dev., 8(4):609-615, 2004.

3
James B. Rawlings, Daniel B. Patience, Eric L. Haseltine, and Philip Dell'Orco.
Stochastic population modeling and application to particle size control in pharmaceutical crystallization.
Annual AIChE Meeting, Indianapolis, IN, November 2002.

4
Daniel B. Patience, Eric L. Haseltine, Philip Dell'Orco, and James B. Rawlings.
Stochastic modeling and control of particle size in crystallization of a pharmaceutical.
World Congress On Particle Technology 4, Sydney, Australia, July 2002.

5
Daniel B. Patience.
Crystal Engineering Through Particle Size and Shape Monitoring, Modeling and Control.
PhD thesis, University of Wisconsin-Madison, June 2002.

6
Daniel B. Patience, Eric L. Haseltine, Phillip Dell'Orco, and James B. Rawlings.
Crystallization of a pharmaceutical. experimental data and stochastic modeling of particle size and shape.
Annual AIChE Meeting, Reno, Nevada, November 2001.

7
Daniel B. Patience, James B. Rawlings, and Hazim A. Mohameed.
Crystallization of para-xylene in scraped-surface crystallizers.
AIChE J., 47(11):2441-2451, November 2001.

8
Daniel B. Patience and James B. Rawlings.
Particle-shape monitoring and control in crystallization processes.
AIChE J., 47(9):2125-2130, September 2001.

9
Daniel B. Patience and James B. Rawlings.
On-line monitoring and modeling of crystal shape in crystallization processes.
Annual AIChE Meeting, Los Angeles, California, November 2000.

10
James B. Rawlings and Daniel B. Patience.
Measuring, modeling and controlling particle size and shape in crystallization processes.
First Symposium on Particulate Processes, Max-Planck-Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany, October 12-13, 2000.

11
James B. Rawlings and Daniel B. Patience.
On-line monitoring of crystal shape in crystallization processes.
Annual Meeting of the International Fine Particle Research Institute, Den Haag, The Netherlands, July 2000.

12
James B. Rawlings and Daniel B. Patience.
Authors' reply to letter to the editor.
AIChE J., 45(8):1842-1843, August 1999.

13
James B. Rawlings and Daniel B. Patience.
On-line monitoring and control of crystal size and shape.
Annual Meeting of the International Fine Particle Research Institute, Somerset, New Jersey, June 1999.

14
Daniel B. Patience, Hazim Mohameed, and James B. Rawlings.
The kinetics of para-xylene crystallization in scraped surface crystallizers.
Association for Crystallization Technology, ACT 9, Kingsport, Tennessee, April 19-21, 1999.

15
Daniel B. Patience and James B. Rawlings.
On-line monitoring and stochastic modelling of particle size distributions.
Annual Meeting of the International Fine Particle Research Institute, Brighton, England, July 1998.

16
Daniel B. Patience and James B. Rawlings.
On-line monitoring and stochastic modelling of particle size distributions.
Annual Meeting of the International Fine Particle Research Institute, Osaka, Japan, June 1997.

Personal Web Page: jbrwww.che.wisc.edu/~daniel

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University of Wisconsin
Department of Chemical Engineering
Madison WI 53706